Predicting substitutions to modulate disorder and stability in coiled-coils

Predicting substitutions to modulate disorder and stability in coiled-coils

Abstract Background Coiled-coils are described as stable structural motifs, where two or more helices wind around each other. However, coiled-coils are associated with local mobility and intrinsic disorder. Intrinsically disordered regions in proteins are characterized by lack of stable secondary an...

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Bibliographic Details
Main Authors: Yasaman Karami, Paul Saighi, Rémy Vanderhaegen, Denis Gerlier, Sonia Longhi, Elodie Laine, Alessandra Carbone
Format: Article
Language:English
Published: BMC 2020-12-01
Series:BMC Bioinformatics
Subjects:
Protein structure
Protein dynamics
Coiled-coil
Molecular dynamics
Protein disorder
Protein stability
Online Access:https://doi.org/10.1186/s12859-020-03867-x

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