Promiscuous binding of invariant chain-derived CLIP peptide to distinct HLA-I molecules revealed in leukemic cells.

Promiscuous binding of invariant chain-derived CLIP peptide to distinct HLA-I molecules revealed in leukemic cells.

Antigen presentation by HLA class I (HLA-I) and HLA class II (HLA-II) complexes is achieved by proteins that are specific for their respective processing pathway. The invariant chain (Ii)-derived peptide CLIP is required for HLA-II-mediated antigen presentation by stabilizing HLA-II molecules before...

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Main Authors: Marvin M van Luijn, Arjan A van de Loosdrecht, Margit H Lampen, Peter A van Veelen, Adri Zevenbergen, Michel G D Kester, Arnoud H de Ru, Gert J Ossenkoppele, Thorbald van Hall, S Marieke van Ham
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22563374/?tool=EBI

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