Carcinoma matrix controls resistance to cisplatin through talin regulation of NF-kB.

Carcinoma matrix controls resistance to cisplatin through talin regulation of NF-kB.

Extracellular matrix factors within the tumor microenvironment that control resistance to chemotherapeutics are poorly understood. This study focused on understanding matrix adhesion pathways that control the oral carcinoma response to cisplatin. Our studies revealed that adhesion of HN12 and JHU012...

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Bibliographic Details
Main Authors: Karen E Eberle, Hope A Sansing, Peter Szaniszlo, Vicente A Resto, Allison L Berrier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3123362?pdf=render

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