Crucial role for BAFF-BAFF-R signaling in the survival and maintenance of mature B cells.

Crucial role for BAFF-BAFF-R signaling in the survival and maintenance of mature B cells.

Defects in the expression of either BAFF (B cell activating factor) or BAFF-R impairs B cell development beyond the immature, transitional type-1 stage and thus, prevents the formation of follicular and marginal zone B cells, whereas B-1 B cells remain unaffected. The expression of BAFF-R on all mat...

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Bibliographic Details
Main Authors: Melanie Rauch, Roxane Tussiwand, Nabil Bosco, Antonius G Rolink
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2673681?pdf=render

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