Nocardia Rubra Cell Wall Skeleton Up-Regulates T Cell Subsets and Inhibits PD-1/PD-L1 Pathway to Promote Local Immune Status of Patients With High-Risk Human Papillomavirus Infection and Cervical Intraepithelial Neoplasia

Nocardia Rubra Cell Wall Skeleton Up-Regulates T Cell Subsets and Inhibits PD-1/PD-L1 Pathway to Promote Local Immune Status of Patients With High-Risk Human Papillomavirus Infection and Cervical Intraepithelial Neoplasia

The Nocardia rubra cell wall skeleton (Nr-CWS) for external use is an immune enhancer, which has been widely used in human cervix diseases such as cervical erosion, but the mechanism of Nr-CWS enhancing immunity is still unclear. The purpose of this study was to explore the effect and mechanism of N...

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Bibliographic Details
Main Authors: Wei Chen, Yi Zhang, Chunfang Zhao, Suxia Shao, Yanan Zhang, Xuehui Li, Xue Bai, Qianyu Guo, Qianwen Liu, Junmin Tang, Lei Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
Nocardia rubra cell wall skeleton
high-risk human papillomavirus
cervical intraepithelial neoplasia
CD4+ T cell
CD8+ T cell
programmed cell death-1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.612547/full

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