Prognostic value of IGF-1R expression in bone and soft tissue sarcomas: comments on a meta-analysis by Liang et al

• Main Authors: Tu C, He J, Li Z
• Format: Article
• Language: English
• Published: Dove Medical Press 2016-04-01
• Series: OncoTargets and Therapy
• Subjects: sarcoma; osteosarcoma; IGF-1R; meta-analysis; comments
• Online Access: https://www.dovepress.com/letter-value-of-igf-1r-expression-in-bone-and-soft-tissue-sar-peer-reviewed-article-OTT

Chao Tu,1 Jieyu He,2 Zhihong Li31Department of Geriatric Surgery, 2Department of Geriatrics, 3Department of Orthopedics and Institute of Senile and Aging Diseases, The Second Xiangya Hospital of Central South University, Changsha, People’s Republic of ChinaRecently, we read with deep interest a meta-analysis by Liang et al entitled “Prognostic value of IGF-1R expression in bone and soft tissue sarcomas: a meta-analysis” published in OncoTargets and Therapy. In this article, the investigators systematically reviewed the trials on the effects of IGF-1R expression in various bone and soft tissue sarcomas (BSTSs) and performed a meta-analysis. They reached an important conclusion that elevated IGF-1R expression was associated with poor overall survival in BSTS patients. Furthermore, subgroup analysis revealed that IGF-1R level was negatively correlated with prognosis in osteosarcoma but not significantly associated with Ewing’s sarcoma. We sincerely appreciate the tremendous effort made by the investigators. Nevertheless, before their results can be accepted, some worthwhile issues need to be addressed first.View original article by Liang et al.