The progression of intracerebral hemorrhage (ICH) is related to the expression of integrin Β1 (ITGB1)

• Main Authors: Hai-Yang Ma, Yan Xu, Chun-You Qiao, Yi Peng, Qi Ding, Li-Zhong Wang, Jun-Fei Yan, Yuan Hou, Fei Di
• Format: Article
• Language: English
• Published: BMC 2021-03-01
• Series: Chinese Neurosurgical Journal
• Subjects: Biomarker; Immunohistochemical staining; Inflammation; Integrins; Intracerebral hemorrhage; Western blotting
• Online Access: https://doi.org/10.1186/s41016-021-00234-4

Abstract Background Intracerebral hemorrhage (ICH) is fatal and detrimental to quality of life. Clinically, options for monitoring are often limited, potentially missing subtle neurological changes. Integrin β 1 (ITGB1) and β 3 (ITGB3) are the main components of integrin family receptors, which regulate the formation and stability of blood vessels. This study explored the relationship between the expression of ITGB1 and ITGB3 in intracerebral hemorrhage (ICH) to analyze their functional and clinical relevance. Methods The expression of ITGB1 and ITGB3 in ICH was accomplished by immunohistochemical (IHC) staining and western blotting (WB) analysis, respectively. Results Furthermore, the results demonstrated that ITGB1 was expressed in ICH tissues, but ITGB3 was not expressed in ICH tissues. Conclusions In summary, the clinical progression of ICH was related to the expression of ITGB1. ITGB1 may be a potential biomarker and contribute to the treatment of ICH.