Exploring Aurone Derivatives as Potential Human Pancreatic Lipase Inhibitors through Molecular Docking and Molecular Dynamics Simulations

Exploring Aurone Derivatives as Potential Human Pancreatic Lipase Inhibitors through Molecular Docking and Molecular Dynamics Simulations

Inhibition of human pancreatic lipase, a crucial enzyme in dietary fat digestion and absorption, is a potent therapeutic approach for obesity treatment. In this study, human pancreatic lipase inhibitory activity of aurone derivatives was explored by molecular modeling approaches. The target protein...

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Bibliographic Details
Main Authors: Phuong Thuy Viet Nguyen, Han Ai Huynh, Dat Van Truong, Thanh-Dao Tran, Cam-Van Thi Vo
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
aurone
human pancreatic lipase
human pancreatic lipase inhibitors
molecular docking
molecular dynamics simulations
Online Access:https://www.mdpi.com/1420-3049/25/20/4657

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