Orexin-A/Hypocretin-1 Controls the VTA-NAc Mesolimbic Pathway via Endocannabinoid-Mediated Disinhibition of Dopaminergic Neurons in Obese Mice

Orexin-A/Hypocretin-1 Controls the VTA-NAc Mesolimbic Pathway via Endocannabinoid-Mediated Disinhibition of Dopaminergic Neurons in Obese Mice

Disinhibition of orexin-A/hypocretin-1 (OX-A) release occurs to several output areas of the lateral hypothalamus (LH) in the brain of leptin knockout obese ob/ob mice. In this study, we have investigated whether a similar increase of OX-A release occurs to the ventral tegmental area (VTA), an orexin...

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Bibliographic Details
Main Authors: Lea Tunisi, Livia D'Angelo, Alba Clara Fernández-Rilo, Nicola Forte, Fabiana Piscitelli, Roberta Imperatore, Paolo de Girolamo, Vincenzo Di Marzo, Luigia Cristino
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
obesity
leptin
reward
orexin
cannabinoid receptor (CB1R)
endocannabinoids
Online Access:https://www.frontiersin.org/articles/10.3389/fnsyn.2021.622405/full

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