Increased Mitochondrial DNA Copy Number and Oxidative Damage in Patients with Hashimoto’s Thyroiditis

• Main Authors: Fatemeh Esfahanian, Mojgan Mirabdolhagh Hazaveh, Laya Hooshmand Garehbagh, Kowsar Falahati, Mitra Ataei, Mohammad Hossein Sanati, Zohreh Jadali
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 2021-07-01
• Series: Iranian Journal of Public Health
• Subjects: Mitochondrial DNA; Hashimoto's thyroiditis; Oxidative stress; Autoimmunity
• Online Access: https://ijph.tums.ac.ir/index.php/ijph/article/view/19484

Background: The purpose of present study was to investigate mitochondrial DNA copy number (mtDNAcn) and mtDNA damage in peripheral blood of patients with Hashimoto's thyroiditis (HT) and healthy controls (HC). Methods: The relative mtDNAcn and oxidative DNA damage in this case-control study were measured in peripheral blood of 50 patients with Hashimoto’s thyroiditis and 50 healthy controls using quantitative real-time PCR. The study was conducted in Tehran University of Medical Sciences hospital, Tehran, Iran in 2018. Results: HT patients had significantly higher mitochondrial DNA copy number and mitochondrial oxidative damage than the comparison group. Conclusion: These data suggest the possible involvement of mitochondria and oxidative stress in the pathophysiology of HT.