Improving Our Understanding of Salmonella enterica Serovar Paratyphi B through the Engineering and Testing of a Live Attenuated Vaccine Strain

Improving Our Understanding of Salmonella enterica Serovar Paratyphi B through the Engineering and Testing of a Live Attenuated Vaccine Strain

We developed a live attenuated Salmonella enterica serovar Paratyphi B vaccine that conferred protection in mice against challenge with S. Paratyphi B sensu stricto and S. Paratyphi B Java, which are the causes of enteric fever and gastroenteritis, respectively. Currently, the incidence of invasive...

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Bibliographic Details
Main Authors: Ellen E. Higginson, Girish Ramachandran, Tracy H. Hazen, Dane A. Kania, David A. Rasko, Marcela F. Pasetti, Myron M. Levine, Sharon M. Tennant
Format: Article
Language:English
Published: American Society for Microbiology 2018-11-01
Series:mSphere
Subjects:
Paratyphi B
Salmonella
genomics
live attenuated
oral vaccines
Online Access:https://doi.org/10.1128/mSphere.00474-18

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