Human Adipose Tissue-Derived Stromal Cells Suppress Human, but Not Murine Lymphocyte Proliferation, via Indoleamine 2,3-Dioxygenase Activity

Over recent years, mesenchymal stromal cells (MSC) have gained immense attraction in immunotherapy, regenerative medicine and tissue engineering. MSC microenvironment modulation occurs through synergy of direct cell–cell contact, and secreted soluble factors and extracellular vesicles (EV). MSC-deri...

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Bibliographic Details
Main Authors: Adriana Torres Crigna, Stefanie Uhlig, Susanne Elvers-Hornung, Harald Klüter, Karen Bieback
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cells
Subjects:
IDO
Online Access:https://www.mdpi.com/2073-4409/9/11/2419