Gentamicin-induced hearing loss: A retrospective study using the Food and Drug Administration Adverse Event Reporting System and a toxicological study using drug−gene network analysis

Gentamicin-induced hearing loss: A retrospective study using the Food and Drug Administration Adverse Event Reporting System and a toxicological study using drug−gene network analysis

The objectives of the study were to evaluate the relationship between gentamicin (GEN) and hearing loss using the Food and Drug Administration Adverse Event Reporting system (FAERS) database and elucidate the potential toxicological mechanism of GEN-induced hearing loss through a drug–gene network a...

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Bibliographic Details
Main Authors: Mizuki Tanaka, Kiyoka Matsumoto, Riko Satake, Yu Yoshida, Misaki Inoue, Shiori Hasegawa, Takaaki Suzuki, Mari Iwata, Kazuhiro Iguchi, Mitsuhiro Nakamura
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Heliyon
Subjects:
Hearing loss
Gentamicin
Aminoglycoside
Food and Drug Administration Adverse Event Reporting System
Protein−protein interaction
Oxidative phosphorylation
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844021015322

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