STAGE-DEPENDENT IMMUNOPATHOGENETIC FEATURES OF ACUTE NONLYMPHOBLASTIC AND ACUTE LYMPHOBLASTIC LEUKEMIA

STAGE-DEPENDENT IMMUNOPATHOGENETIC FEATURES OF ACUTE NONLYMPHOBLASTIC AND ACUTE LYMPHOBLASTIC LEUKEMIA

Abstract. We examined immunological state in 100 patients with acute non-lymphoblastic leukemia (ANLL, M4), and in 73 cases of acute lymphoblastic leukemia (ALL, common variant). The most expressed disturbances of immune status in ANLL patients were revealed during relapses, and in patients with ALL...

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Main Authors: O. V. Smirnova, A. A. Savchenko, V. T. Manchuk
Format: Article
Language:Russian
Published: SPb RAACI 2014-07-01
Series:Medicinskaâ Immunologiâ
Subjects:
immunity
non-lymphoblastic leukemia
lymphoblastic leukemia
Online Access:https://www.mimmun.ru/mimmun/article/view/202
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spelling doaj-c4655c09d0ca4de6975decea35ebf7142021-07-29T09:02:22ZrusSPb RAACIMedicinskaâ Immunologiâ1563-06252313-741X2014-07-0194-544745610.15789/1563-0625-2007-4-5-447-456199STAGE-DEPENDENT IMMUNOPATHOGENETIC FEATURES OF ACUTE NONLYMPHOBLASTIC AND ACUTE LYMPHOBLASTIC LEUKEMIAO. V. Smirnova0A. A. Savchenko1V. T. Manchuk2ГУ НИИ Медицинских проблем Севера СО РАМН, г. КрасноярскГУ НИИ Медицинских проблем Севера СО РАМН, г. КрасноярскГУ НИИ Медицинских проблем Севера СО РАМН, г. КрасноярскAbstract. We examined immunological state in 100 patients with acute non-lymphoblastic leukemia (ANLL, M4), and in 73 cases of acute lymphoblastic leukemia (ALL, common variant). The most expressed disturbances of immune status in ANLL patients were revealed during relapses, and in patients with ALL they were detected in the state of clinical remission. In cases of ANLL, T cell immunodeficiency did develop in crisis and remission, whereas combined T- and B-cell immunodeficiency occurs during relapse of ANLL. T cell immunodeficiency was found to develop at all stages of ALL. These changes and differences may characterize specific immunopathogenetic aspects of development and progression of ANLL and acute ALL.https://www.mimmun.ru/mimmun/article/view/202immunitynon-lymphoblastic leukemialymphoblastic leukemia
collection DOAJ
language Russian
format Article
sources DOAJ
author O. V. Smirnova
A. A. Savchenko
V. T. Manchuk
spellingShingle O. V. Smirnova
A. A. Savchenko
V. T. Manchuk
STAGE-DEPENDENT IMMUNOPATHOGENETIC FEATURES OF ACUTE NONLYMPHOBLASTIC AND ACUTE LYMPHOBLASTIC LEUKEMIA
Medicinskaâ Immunologiâ
immunity
non-lymphoblastic leukemia
lymphoblastic leukemia
author_facet O. V. Smirnova
A. A. Savchenko
V. T. Manchuk
author_sort O. V. Smirnova
title STAGE-DEPENDENT IMMUNOPATHOGENETIC FEATURES OF ACUTE NONLYMPHOBLASTIC AND ACUTE LYMPHOBLASTIC LEUKEMIA
title_short STAGE-DEPENDENT IMMUNOPATHOGENETIC FEATURES OF ACUTE NONLYMPHOBLASTIC AND ACUTE LYMPHOBLASTIC LEUKEMIA
title_full STAGE-DEPENDENT IMMUNOPATHOGENETIC FEATURES OF ACUTE NONLYMPHOBLASTIC AND ACUTE LYMPHOBLASTIC LEUKEMIA
title_fullStr STAGE-DEPENDENT IMMUNOPATHOGENETIC FEATURES OF ACUTE NONLYMPHOBLASTIC AND ACUTE LYMPHOBLASTIC LEUKEMIA
title_full_unstemmed STAGE-DEPENDENT IMMUNOPATHOGENETIC FEATURES OF ACUTE NONLYMPHOBLASTIC AND ACUTE LYMPHOBLASTIC LEUKEMIA
title_sort stage-dependent immunopathogenetic features of acute nonlymphoblastic and acute lymphoblastic leukemia
publisher SPb RAACI
series Medicinskaâ Immunologiâ
issn 1563-0625
2313-741X
publishDate 2014-07-01
description Abstract. We examined immunological state in 100 patients with acute non-lymphoblastic leukemia (ANLL, M4), and in 73 cases of acute lymphoblastic leukemia (ALL, common variant). The most expressed disturbances of immune status in ANLL patients were revealed during relapses, and in patients with ALL they were detected in the state of clinical remission. In cases of ANLL, T cell immunodeficiency did develop in crisis and remission, whereas combined T- and B-cell immunodeficiency occurs during relapse of ANLL. T cell immunodeficiency was found to develop at all stages of ALL. These changes and differences may characterize specific immunopathogenetic aspects of development and progression of ANLL and acute ALL.
topic immunity
non-lymphoblastic leukemia
lymphoblastic leukemia
url https://www.mimmun.ru/mimmun/article/view/202
work_keys_str_mv AT ovsmirnova stagedependentimmunopathogeneticfeaturesofacutenonlymphoblasticandacutelymphoblasticleukemia
AT aasavchenko stagedependentimmunopathogeneticfeaturesofacutenonlymphoblasticandacutelymphoblasticleukemia
AT vtmanchuk stagedependentimmunopathogeneticfeaturesofacutenonlymphoblasticandacutelymphoblasticleukemia
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