Development and Palatability Assessment of Norvir<sup>®</sup> (Ritonavir) 100 mg Powder for Pediatric Population
Norvir<sup>®</sup> (ritonavir) is a Biopharmaceutical Classification System Class IV compound with poor solubility in water (~5 µg/mL) and limited oral bioavailability. Early stage development efforts were focused on an oral solution (OS) which provided reasonable bioav...
Main Authors: | John B. Morris, David A. Tisi, David Cheng Thiam Tan, Jeffrey H. Worthington |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-04-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/20/7/1718 |
Similar Items
-
Thymoquinone-Loaded Soluplus<sup>®</sup>-Solutol<sup>®</sup> HS15 Mixed Micelles: Preparation, In Vitro Characterization, and Effect on the SH-SY5Y Cell Migration
by: Maria Camilla Bergonzi, et al.
Published: (2020-10-01) -
Comparison of Flow and Compression Properties of Four Lactose-Based Co-Processed Excipients: Cellactose<sup>®</sup> 80, CombiLac<sup>®</sup>, MicroceLac<sup>®</sup> 100, and StarLac<sup>®</sup>
by: Martin Dominik, et al.
Published: (2021-09-01) -
Role of Intracellular Na<sup>+</sup> in the Regulation of [Ca<sup>2+</sup>]<sub>i</sub> in the Rat Suprachiasmatic Nucleus Neurons
by: Ruo-Ciao Cheng, et al.
Published: (2019-09-01) -
Identification of the Impurities in Bopu Powder<sup>®</sup> and Sangrovit<sup>®</sup> by LC-MS Combined with a Screening Method
by: Zhuang Dong, et al.
Published: (2021-06-01) -
Improved Dissolution and Oral Bioavailability of Valsartan Using a Solidified Supersaturable Self-Microemulsifying Drug Delivery System Containing Gelucire<sup>®</sup> 44/14
by: Dong Jun Shin, et al.
Published: (2019-01-01)