Cancer Stem Cell Radioresistance and Enrichment: Where Frontline Radiation Therapy May Fail in Lung and Esophageal Cancers

Cancer Stem Cell Radioresistance and Enrichment: Where Frontline Radiation Therapy May Fail in Lung and Esophageal Cancers

Many studies have highlighted the role cancer stem cells (CSC) play in the development and progression of various types of cancer including lung and esophageal cancer. More recently, it has been proposed that the presence of CSCs affects treatment efficacy and patient prognosis. In reviewing this ne...

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Bibliographic Details
Main Authors: Joe Y. Chang, Mandi M. Murph, Giang Huong Nguyen
Format: Article
Language:English
Published: MDPI AG 2011-03-01
Series:Cancers
Subjects:
cancer stem cells
lung cancer
esophageal cancer
radiation therapy
Online Access:http://www.mdpi.com/2072-6694/3/1/1232/
Description
Summary:Many studies have highlighted the role cancer stem cells (CSC) play in the development and progression of various types of cancer including lung and esophageal cancer. More recently, it has been proposed that the presence of CSCs affects treatment efficacy and patient prognosis. In reviewing this new area of cancer biology, we will give an overview of the current literature regarding lung and esophageal CSCs and radioresistance of CSC, and discuss the potential therapeutic applications of these findings.
ISSN:2072-6694

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