Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases
Pinoresinol–lariciresinol reductases (PLRs) are enzymes involved in the lignan biosynthesis. Here, crystal structures of three PLRs in the apo, substrate-bound and product-bound states, and accompanying mutagenesis provide insight into PLRs catalytic mechanism and suggest a strategy for PLR engineer...
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Bibliographic Details
| Main Authors: |
Ying Xiao,
Kai Shao,
Jingwen Zhou,
Lian Wang,
Xueqi Ma,
Di Wu,
Yingbo Yang,
Junfeng Chen,
Jingxian Feng,
Shi Qiu,
Zongyou Lv,
Lei Zhang,
Peng Zhang,
Wansheng Chen |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-05-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-23095-y
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