Molecular study of the perforin gene in familial hematological malignancies

Molecular study of the perforin gene in familial hematological malignancies

<p>Abstract</p> <p>Perforin gene (<it>PRF1</it>) mutations have been identified in some patients diagnosed with the familial form of hemophagocytic lymphohistiocytosis (HLH) and in patients with lymphoma. The aim of the present study was to determine whether patients wi...

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Main Authors: El Abed Rim, Bourdon Violaine, Voskoboinik Ilia, Omri Halima, Youssef Yosra, Laatiri Mohamed, Huiart Laetitia, Eisinger François, Rabayrol Laetitia, Frenay Marc, Gesta Paul, Demange Liliane, Dreyfus Hélène, Bonadona Valérie, Dugast Catherine, Zattara Hélène, Faivre Laurence, Zaier Monia, Jemni Saloua, Noguchi Testsuro, Sobol Hagay, Soua Zohra
Format: Article
Language:English
Published: BMC 2011-09-01
Series:Hereditary Cancer in Clinical Practice
Subjects:
<it>PRF1</it>
germline mutation
hematological familial malignancies
Online Access:http://www.hccpjournal.com/content/9/1/9

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