Evaluation of the role of digital rectal examination and prostate specific antigen in diagnosis of prostate cancer

• Main Authors: Harun Çıralık, Remziye Eren, Mustafa Eren, Mustafa Remzi Bahar, Bülent Altunoluk, Sefa Resim
• Format: Article
• Language: English
• Published: Modestum Publishing LTD 2012-03-01
• Series: Journal of Clinical and Experimental Investigations
• Subjects: Prostate cancer; prostate biopsy; prostate specific antigen; digital rectal examination
• Online Access: http://www.jceionline.org/upload/sayi/8/JCEI-00433.pdf

Objectives: In this study, we examined the value of prostatespecific antigen (PSA) and digital rectal examination(DRE) in prostate cancer detection among men.Materials and methods: Between January 2006 and July2011, transrectal prostate needle biopsy was performedin 349 patients with abnormal DRE and/or >4ng/ml serumtotal PSA level were involved in the study. According tothe histopathological examination, the patients were dividedinto two groups as without and with prostate cancerand their data were compared.Results: At the end of the histopathological examination,121 (32.4%) cases had prostate cancer and 252 (67.6%)cases found without prostate cancer. Mean age and meanPSA values were higher and prostate volume was lowerin the prostate cancer group than the other group. Prostatecancer was detected in 73 of the patients (66.4%)whose DRE was abnormal. In prostate cancer group,Gleason scores of 47 patients’ (38.8%) were “6”, Gleasonscores of 42 patients’ (34.7%) were “ 7” and Gleasonscores of 32 patients’ (26.5%) were between 8 and 10.Positive predictive values for high serum total PSA level(>4 ng/ml) and abnormal DRE were found as 39.7% and66.4% respectively.Conclusions: Only serum total PSA measurement oronly DRE is inadequate differential methods for differentiationof benign and malign prostate diseases. WhenDRE was assessed with serum total PSA level, cancerdetection rate and reliability increases. J Clin Exp Invest2012; 3(1): 66-70