Genomic and transcriptomic alterations associated with drug vulnerabilities and prognosis in adenocarcinoma at the gastroesophageal junction

Genomic and transcriptomic alterations associated with drug vulnerabilities and prognosis in adenocarcinoma at the gastroesophageal junction

Adenocarcinoma at the gastroesophageal junction has a dismal prognosis and few drug options. Here, the authors present genomic and transcriptomic features and potential therapeutic targets and prognostic biomarkers of Chinese and Caucasian tumours, and reveal the molecular similarities.

Bibliographic Details
Main Authors: Yuan Lin, Yingying Luo, Yanxia Sun, Wenjia Guo, Xuan Zhao, Yiyi Xi, Yuling Ma, Mingming Shao, Wen Tan, Ge Gao, Chen Wu, Dongxin Lin
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19949-6
id doaj-c436c63633644f689042acf518860914
record_format Article
spelling doaj-c436c63633644f689042acf5188609142021-05-11T08:05:59ZengNature Publishing GroupNature Communications2041-17232020-11-0111111410.1038/s41467-020-19949-6Genomic and transcriptomic alterations associated with drug vulnerabilities and prognosis in adenocarcinoma at the gastroesophageal junctionYuan Lin0Yingying Luo1Yanxia Sun2Wenjia Guo3Xuan Zhao4Yiyi Xi5Yuling Ma6Mingming Shao7Wen Tan8Ge Gao9Chen Wu10Dongxin Lin11Beijing Advanced Innovation Center for Genomics (ICG), Biomedical Pioneering Innovation Center (BIOPIC), Peking UniversityDepartment of Etiology and Carcinogenesis, National Cancer Center/National Clinical Research Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Etiology and Carcinogenesis, National Cancer Center/National Clinical Research Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Etiology and Carcinogenesis, National Cancer Center/National Clinical Research Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Etiology and Carcinogenesis, National Cancer Center/National Clinical Research Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Etiology and Carcinogenesis, National Cancer Center/National Clinical Research Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Etiology and Carcinogenesis, National Cancer Center/National Clinical Research Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Etiology and Carcinogenesis, National Cancer Center/National Clinical Research Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Etiology and Carcinogenesis, National Cancer Center/National Clinical Research Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing Advanced Innovation Center for Genomics (ICG), Biomedical Pioneering Innovation Center (BIOPIC), Peking UniversityDepartment of Etiology and Carcinogenesis, National Cancer Center/National Clinical Research Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Etiology and Carcinogenesis, National Cancer Center/National Clinical Research Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeAdenocarcinoma at the gastroesophageal junction has a dismal prognosis and few drug options. Here, the authors present genomic and transcriptomic features and potential therapeutic targets and prognostic biomarkers of Chinese and Caucasian tumours, and reveal the molecular similarities.https://doi.org/10.1038/s41467-020-19949-6
collection DOAJ
language English
format Article
sources DOAJ
author Yuan Lin
Yingying Luo
Yanxia Sun
Wenjia Guo
Xuan Zhao
Yiyi Xi
Yuling Ma
Mingming Shao
Wen Tan
Ge Gao
Chen Wu
Dongxin Lin
spellingShingle Yuan Lin
Yingying Luo
Yanxia Sun
Wenjia Guo
Xuan Zhao
Yiyi Xi
Yuling Ma
Mingming Shao
Wen Tan
Ge Gao
Chen Wu
Dongxin Lin
Genomic and transcriptomic alterations associated with drug vulnerabilities and prognosis in adenocarcinoma at the gastroesophageal junction
Nature Communications
author_facet Yuan Lin
Yingying Luo
Yanxia Sun
Wenjia Guo
Xuan Zhao
Yiyi Xi
Yuling Ma
Mingming Shao
Wen Tan
Ge Gao
Chen Wu
Dongxin Lin
author_sort Yuan Lin
title Genomic and transcriptomic alterations associated with drug vulnerabilities and prognosis in adenocarcinoma at the gastroesophageal junction
title_short Genomic and transcriptomic alterations associated with drug vulnerabilities and prognosis in adenocarcinoma at the gastroesophageal junction
title_full Genomic and transcriptomic alterations associated with drug vulnerabilities and prognosis in adenocarcinoma at the gastroesophageal junction
title_fullStr Genomic and transcriptomic alterations associated with drug vulnerabilities and prognosis in adenocarcinoma at the gastroesophageal junction
title_full_unstemmed Genomic and transcriptomic alterations associated with drug vulnerabilities and prognosis in adenocarcinoma at the gastroesophageal junction
title_sort genomic and transcriptomic alterations associated with drug vulnerabilities and prognosis in adenocarcinoma at the gastroesophageal junction
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-11-01
description Adenocarcinoma at the gastroesophageal junction has a dismal prognosis and few drug options. Here, the authors present genomic and transcriptomic features and potential therapeutic targets and prognostic biomarkers of Chinese and Caucasian tumours, and reveal the molecular similarities.
url https://doi.org/10.1038/s41467-020-19949-6
work_keys_str_mv AT yuanlin genomicandtranscriptomicalterationsassociatedwithdrugvulnerabilitiesandprognosisinadenocarcinomaatthegastroesophagealjunction
AT yingyingluo genomicandtranscriptomicalterationsassociatedwithdrugvulnerabilitiesandprognosisinadenocarcinomaatthegastroesophagealjunction
AT yanxiasun genomicandtranscriptomicalterationsassociatedwithdrugvulnerabilitiesandprognosisinadenocarcinomaatthegastroesophagealjunction
AT wenjiaguo genomicandtranscriptomicalterationsassociatedwithdrugvulnerabilitiesandprognosisinadenocarcinomaatthegastroesophagealjunction
AT xuanzhao genomicandtranscriptomicalterationsassociatedwithdrugvulnerabilitiesandprognosisinadenocarcinomaatthegastroesophagealjunction
AT yiyixi genomicandtranscriptomicalterationsassociatedwithdrugvulnerabilitiesandprognosisinadenocarcinomaatthegastroesophagealjunction
AT yulingma genomicandtranscriptomicalterationsassociatedwithdrugvulnerabilitiesandprognosisinadenocarcinomaatthegastroesophagealjunction
AT mingmingshao genomicandtranscriptomicalterationsassociatedwithdrugvulnerabilitiesandprognosisinadenocarcinomaatthegastroesophagealjunction
AT wentan genomicandtranscriptomicalterationsassociatedwithdrugvulnerabilitiesandprognosisinadenocarcinomaatthegastroesophagealjunction
AT gegao genomicandtranscriptomicalterationsassociatedwithdrugvulnerabilitiesandprognosisinadenocarcinomaatthegastroesophagealjunction
AT chenwu genomicandtranscriptomicalterationsassociatedwithdrugvulnerabilitiesandprognosisinadenocarcinomaatthegastroesophagealjunction
AT dongxinlin genomicandtranscriptomicalterationsassociatedwithdrugvulnerabilitiesandprognosisinadenocarcinomaatthegastroesophagealjunction
_version_ 1721451202500100096

Similar Items