Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signaling.

Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signaling.

Glucose-regulated protein 94 (GRP94) is one of the most abundant endoplasmic reticulum (ER) resident proteins and is the ER counterpart of the cytoplasmic heat shock protein 90 (HSP90). GRP94, a component of the GRP78 chaperone system in protein processing, has pro-survival properties with implicate...

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Bibliographic Details
Main Authors:	Changhui Mao, Miao Wang, Biquan Luo, Shiuan Wey, Dezheng Dong, Robin Wesselschmidt, Stephen Rawlings, Amy S Lee
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2010-05-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC2877114?pdf=render

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