HYCO-3, a dual CO-releaser/Nrf2 activator, reduces tissue inflammation in mice challenged with lipopolysaccharide

HYCO-3, a dual CO-releaser/Nrf2 activator, reduces tissue inflammation in mice challenged with lipopolysaccharide

Oxidative stress and inflammation are predominant features of several chronic diseases. The nuclear factor erythroid 2-related factor 2 (Nrf2) is a major arbiter in counteracting these insults via up-regulation of several defensive proteins, including heme oxygenase-1 (HO-1). HO-1-derived carbon mon...

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Bibliographic Details
Main Authors:	Roberto Motterlini, Aniket Nikam, Sylvie Manin, Anthony Ollivier, Jayne Louise Wilson, Sabrina Djouadi, Lucie Muchova, Thierry Martens, Michael Rivard, Roberta Foresti
Format:	Article
Language:	English
Published:	Elsevier 2019-01-01
Series:	Redox Biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231718308693

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