Are Pathogenic Germline Variants in Metastatic Melanoma Associated with Resistance to Combined Immunotherapy?

Are Pathogenic Germline Variants in Metastatic Melanoma Associated with Resistance to Combined Immunotherapy?

Background: Combined immunotherapy has significantly improved survival of patients with advanced melanoma, but there are still patients that do not benefit from it. Early biomarkers that indicate potential resistance would be highly relevant for these patients. Methods: We comprehensively analyzed t...

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Bibliographic Details
Main Authors: Teresa Amaral, Martin Schulze, Tobias Sinnberg, Maike Nieser, Peter Martus, Florian Battke, Claus Garbe, Saskia Biskup, Andrea Forschner
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
pathogenic/likely pathogenic germline variant
immune checkpoint inhibitors
advanced melanoma
resistance to immunotherapy
Online Access:https://www.mdpi.com/2072-6694/12/5/1101

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