Preclinical examination of complex antimicrobial preparation for treating endometritis in cows

• Main Authors: Koba Igor, Shantyz Azamat, Novicova Elena, Odeh Abdl-mu’tee Omar, Daytlov Nikita
• Format: Article
• Language: English
• Published: EDP Sciences 2020-01-01
• Series: BIO Web of Conferences
• Online Access: https://www.bio-conferences.org/articles/bioconf/full_html/2020/01/bioconf_fies2020_00186/bioconf_fies2020_00186.html

According to a statistical study an average of 40 % of infertile animals have obstetric and gynecological pathologies. Among obstetric and gynecological pathologies, the most common is an acute postpartum endometritis, which make up from 37.8 to 41 %. Therapy and Pharmacology department of the Kuban State Agrarian University has developed a drug for the cows postpartum endometritis treatment. Conducted preclinical tests prove its harmlessness, as a result of which it belongs to hazard class 4. It should be noted that the biochemical blood parameters of rats in the experiment do not go beyond the reference values. The drug has a pronounced antimicrobial effect. MBC is from 7.8 mg to 31.2 mg while MIC is from 31.2 to 62.5 mg for such strains as S. aureus, E. coli, St. xylosus, Ps. aeruginosa, P. vulgaris. The developed drug does not have an irritating and sensitizing effect and exhibits a regenerative effect. Conducted experiments on the wound healing effect of the drug prove that this drug has a high regenerative effect. The average wound healing area was 20.4 % per day.