Clinical features, management and visual outcome of polypoidal choroidal vasculopathy in Indian patients

• Main Authors: Anantharaman Giridhar, Ramkumar Gudapati, Gopalakrishnan Mahesh, Rajput Alpesh
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2010-01-01
• Series: Indian Journal of Ophthalmology
• Subjects: Greatest linear diameter; indocyanine green angiography; photodynamic therapy; polypoidal choroidal vasculopathy; serosanguinous maculopathy; submacular hemorrhage; thermal laser
• Online Access: http://www.ijo.in/article.asp?issn=0301-4738;year=2010;volume=58;issue=5;spage=399;epage=405;aulast=Anantharaman
• ISSN: 0301-4738; 1998-3689

<b>Aims:</b> To present the clinical, indocyanine green angiography (ICGA) features and results of treatment for polypoidal choroidal vasculopathy (PCV) in Indian patients by a retrospective chart review.<b>Materials and Methods:</b> Forty five patients with PCV underwent complete ocular examination, fluorescein angiography (FFA) and ICGA. Treatment was advised for patients with macular involvement and progressive loss of visual acuity. Demographic data, clinical features and results of treatment were analyzed.<b>Results:</b> Mean age at presentation was 61.06 years. Mean follow up was 18 months. The disease was more prevalent in males. Forty three patients had unilateral disease. The most common location of polyps in ICGA was subfoveal (42.5&#x0025;). Exudative form was seen in 34 of the 47 eyes and the remaining 13 eyes had a hemorrhagic presentation. Thirty four eyes underwent treatment which included thermal laser (<i>n</i> = 11), photodynamic therapy (PDT) (<i>n</i> = 11) and transpupillary thermo therapy (TTT) (<i>n</i> = 12). Statistical analysis was done using the Chi-square test. Subgroup analysis of visual outcome following various modalities of treatment showed that the results of PDT (<i>P</i> &lt; 0.001) and thermal laser (<i>P</i> &lt; 0.001) were statistically significant. <b>Conclusions:</b> PCV is an important differential diagnosis in patients presenting with serosanginous maculopathy and submacular hemorrhage. The disease was more prevalent in males and was unilateral in the Indian population. Timely intervention in cases with symptomatic polyps could achieve stabilization of visual acuity. Thermal laser and PDT were safe and effective.