Massive B-Cell Infiltration and Organization Into Artery Tertiary Lymphoid Organs in the Aorta of Large Vessel Giant Cell Arteritis

Massive B-Cell Infiltration and Organization Into Artery Tertiary Lymphoid Organs in the Aorta of Large Vessel Giant Cell Arteritis

Giant cell arteritis (GCA) can be classified into Cranial(C)-GCA and Large Vessel(LV)-GCA. Based on analysis of temporal arteries, GCA is postulated to be T-cell-mediated. Recently, a disturbed B-cell homeostasis was documented in newly diagnosed GCA patients. In the current study, we assessed the p...

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Bibliographic Details
Main Authors: Jacoba C. Graver, Annemieke M. H. Boots, Erlin A. Haacke, Arjan Diepstra, Elisabeth Brouwer, Maria Sandovici
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
giant cell arteritis
B-cell
tertiary lymphoid organs
aorta
plasma cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00083/full

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