An EBNA3C-deleted Epstein-Barr virus (EBV) mutant causes B-cell lymphomas with delayed onset in a cord blood-humanized mouse model.

An EBNA3C-deleted Epstein-Barr virus (EBV) mutant causes B-cell lymphomas with delayed onset in a cord blood-humanized mouse model.

EBV causes human B-cell lymphomas and transforms B cells in vitro. EBNA3C, an EBV protein expressed in latently-infected cells, is required for EBV transformation of B cells in vitro. While EBNA3C undoubtedly plays a key role in allowing EBV to successfully infect B cells, many EBV+ lymphomas do not...

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Bibliographic Details
Main Authors: James C Romero-Masters, Makoto Ohashi, Reza Djavadian, Mark R Eichelberg, Mitch Hayes, Jillian A Bristol, Shidong Ma, Erik A Ranheim, Jenny Gumperz, Eric C Johannsen, Shannon C Kenney
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-08-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC6117096?pdf=render

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