The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome

The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome

Abstract Background Although immune modulation is a promising therapeutic avenue in coronavirus disease 2019 (COVID-19), the most relevant targets remain to be found. COVID-19 has peculiar characteristics and outcomes, suggesting a unique immunopathogenesis. Methods Thirty-six immunocompetent non-CO...

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Bibliographic Details
Main Authors: Mathieu Blot, Jean-Baptiste Bour, Jean Pierre Quenot, Abderrahmane Bourredjem, Maxime Nguyen, Julien Guy, Serge Monier, Marjolaine Georges, Audrey Large, Auguste Dargent, Alexandre Guilhem, Suzanne Mouries-Martin, Jeremy Barben, Belaid Bouhemad, Pierre-Emmanuel Charles, Pascal Chavanet, Christine Binquet, Lionel Piroth, for the LYMPHONIE study group
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Journal of Translational Medicine
Subjects:
COVID-19
Acute respiratory distress syndrome
Pneumonia
Immune response
CXCL10
GM-CSF
Online Access:https://doi.org/10.1186/s12967-020-02646-9

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