Involvement of Endothelin and ETAEndothelin Receptor in Mechanical Allodynia in Mice Given Orthotopic Melanoma Inoculation

Involvement of Endothelin and ETAEndothelin Receptor in Mechanical Allodynia in Mice Given Orthotopic Melanoma Inoculation

We investigated whether endothelin (ET) would be involved in skin cancer pain in mice. Orthotopic inoculation of B16-BL6 melanoma cells into the plantar region of the hind paw produced marked mechanical allodynia in C57BL/6 mice. Intraplantar injections of the ETA- receptor antagonist BQ-123 (0.3 –3...

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Bibliographic Details
Main Authors:	Masahide Fujita, Tsugunobu Andoh, Ikuo Saiki, Yasushi Kuraishi
Format:	Article
Language:	English
Published:	Elsevier 2008-01-01
Series:	Journal of Pharmacological Sciences
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861319315208

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