The missing linker between SUN5 and PMFBP1 in sperm head-tail coupling apparatus

The missing linker between SUN5 and PMFBP1 in sperm head-tail coupling apparatus

The sperm head-to-tail coupling apparatus ensures sperm head-tail integrity, but mechanistic insights remain limited. Here the authors demonstrate that CENTLEIN links and controls the interaction between SUN5 and PMFBP1, indicating that its impairments might be associated with acephalic spermatozoa...

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Main Authors: Ying Zhang, Chao Liu, Bingbing Wu, Liansheng Li, Wei Li, Li Yuan
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25227-w
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spelling doaj-c3e00da18c8d487792d8bd601dd989802021-08-15T11:40:11ZengNature Publishing GroupNature Communications2041-17232021-08-0112111610.1038/s41467-021-25227-wThe missing linker between SUN5 and PMFBP1 in sperm head-tail coupling apparatusYing Zhang0Chao Liu1Bingbing Wu2Liansheng Li3Wei Li4Li Yuan5Savaid Medical School, University of Chinese Academy of SciencesFertility Preservation Lab, Reproductive Medicine Center, Guangdong Second Provincial General HospitalState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Stem Cell and Regenerative Medicine Innovation Institute, Chinese Academy of SciencesSavaid Medical School, University of Chinese Academy of SciencesFertility Preservation Lab, Reproductive Medicine Center, Guangdong Second Provincial General HospitalSavaid Medical School, University of Chinese Academy of SciencesThe sperm head-to-tail coupling apparatus ensures sperm head-tail integrity, but mechanistic insights remain limited. Here the authors demonstrate that CENTLEIN links and controls the interaction between SUN5 and PMFBP1, indicating that its impairments might be associated with acephalic spermatozoa syndrome.https://doi.org/10.1038/s41467-021-25227-w
collection DOAJ
language English
format Article
sources DOAJ
author Ying Zhang
Chao Liu
Bingbing Wu
Liansheng Li
Wei Li
Li Yuan
spellingShingle Ying Zhang
Chao Liu
Bingbing Wu
Liansheng Li
Wei Li
Li Yuan
The missing linker between SUN5 and PMFBP1 in sperm head-tail coupling apparatus
Nature Communications
author_facet Ying Zhang
Chao Liu
Bingbing Wu
Liansheng Li
Wei Li
Li Yuan
author_sort Ying Zhang
title The missing linker between SUN5 and PMFBP1 in sperm head-tail coupling apparatus
title_short The missing linker between SUN5 and PMFBP1 in sperm head-tail coupling apparatus
title_full The missing linker between SUN5 and PMFBP1 in sperm head-tail coupling apparatus
title_fullStr The missing linker between SUN5 and PMFBP1 in sperm head-tail coupling apparatus
title_full_unstemmed The missing linker between SUN5 and PMFBP1 in sperm head-tail coupling apparatus
title_sort missing linker between sun5 and pmfbp1 in sperm head-tail coupling apparatus
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-08-01
description The sperm head-to-tail coupling apparatus ensures sperm head-tail integrity, but mechanistic insights remain limited. Here the authors demonstrate that CENTLEIN links and controls the interaction between SUN5 and PMFBP1, indicating that its impairments might be associated with acephalic spermatozoa syndrome.
url https://doi.org/10.1038/s41467-021-25227-w
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AT lianshengli themissinglinkerbetweensun5andpmfbp1inspermheadtailcouplingapparatus
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AT bingbingwu missinglinkerbetweensun5andpmfbp1inspermheadtailcouplingapparatus
AT lianshengli missinglinkerbetweensun5andpmfbp1inspermheadtailcouplingapparatus
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AT liyuan missinglinkerbetweensun5andpmfbp1inspermheadtailcouplingapparatus
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