Role of markers for acute kidney injury in surgical management of patients with renal cancer

• Main Authors: O. I. Kit, E. M. Frantsiyants, S. N. Dimitriadi, I. V. Kaplieva, L. K. Trepitaki, N. D. Cheryarina, Yu. A. Pogorelova
• Format: Article
• Language: Russian
• Published: ABV-press 2015-09-01
• Series: Onkourologiâ
• Subjects: acute kidney injury; renal cancer; cystatin c; interleukin-18; the marker lipocalin-2 marker (ngal); the marker of l-fabp; the marker kidney injury molecule-1 (kim-1); warm ischemia time; enzyme immunoassay; laparoscopic partial nephrectomy
• Online Access: https://oncourology.abvpress.ru/oncur/article/view/485
• ISSN: 1726-9776; 1996-1812

The paper gives the results of studying the urinary levels of markers of acute kidney injury (AKI) in 46 patients with renal cancer during separate ureteral catheterization before the surgery and 24 hours after laparoscopic partial nephrectomy performed due to elective indications under warm ischemia. The levels of cystatin C, neutrophil gelatinase-associated lipocalin (NGAL), liver-type fatty acid-binding protein (L-FABP), and interleukin-18 were examined by enzyme immunoassay. It has been established that the risk of early postoperative AKI may be predicted from the baseline urinary levels of cystatin C and LFABP in patients with renal cancer resulting from 15-20-min warm ischemia time during the partial nephrectomy. An approach based on estimation of the baseline urinary levels of cystatin C and L-FABP to be incorporated into a preoperative examination scheme is proposed for surgical treatment policy choosing in patients with renal cancer. A scheme for examining patients with renal cancer is also suggested for the risk of complications and the degree of AKI assessing in the early post-operative period.