Interleukin-4 (IL-4) enhances and soluble interleukin-4 receptor (sIL-4R) inhibits histamine release from peripheral blood basophils and mast cells in vitro and in vivo

Interleukin-4 (IL-4) enhances and soluble interleukin-4 receptor (sIL-4R) inhibits histamine release from peripheral blood basophils and mast cells in vitro and in vivo

The aim of the study was to analyse the effect of interleukin-4 (IL-4) on allergen and anti-IgE mediated histamine release from basophils and human skin mast cells and to assess whether soluble recombinant interleukin-4 receptor (sIL4R) can inhibit these effects. Anti-IgE stimulated histamine releas...

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Bibliographic Details
Main Authors: B. Niggemann, T. Zuberbier, U. Herz, K. Enssle, U. Wahn, H. Renz
Format: Article
Language:English
Published: Hindawi Limited 1997-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1080/09629359791802

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