Assessment of Immune Response Following Dendritic Cell-Based Immunotherapy in Pediatric Patients With Relapsing Sarcoma

Assessment of Immune Response Following Dendritic Cell-Based Immunotherapy in Pediatric Patients With Relapsing Sarcoma

Monocyte-derived dendritic cell (DC)-based vaccines loaded with tumor self-antigens represent a novel approach in anticancer therapy. We evaluated DC-based anticancer immunotherapy (ITx) in an academic Phase I/II clinical trial for children, adolescent, and young adults with progressive, recurrent,...

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Bibliographic Details
Main Authors: Lenka Fedorova, Peter Mudry, Katerina Pilatova, Iveta Selingerova, Jana Merhautova, Zdenek Rehak, Dalibor Valik, Eva Hlavackova, Dasa Cerna, Lucie Faberova, Pavel Mazanek, Zdenek Pavelka, Regina Demlova, Jaroslav Sterba, Lenka Zdrazilova-Dubska
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Oncology
Subjects:
dendritic cells
anticancer immunotherapy
dendritic-cell (DC)-based vaccine
pediatric sarcoma
academic clinical trials
immunomonitoring
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01169/full

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