Metabolic Syndrome and Psoriasis: Mechanisms and Future Directions

Psoriasis is an immune-mediated systemic disease with associated comorbidities, including metabolic syndrome (MetS) which contributes substantially to premature mortality in patients with psoriasis. However, the pathological mechanisms underlying this comorbidity are unclear. Studies have shown that...

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Main Authors:	Yan Hao, Ya-juan Zhu, Song Zou, Pei Zhou, Ya-wen Hu, Qi-xiang Zhao, Lin-na Gu, Hao-zhou Zhang, Zhen Wang, Jiong Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-07-01
Series:	Frontiers in Immunology
Subjects:	psoriasis metabolic syndrome gut microbiota insulin resistance autoimmunity obesity
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.711060/full

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spelling	doaj-c3abb25323fb4d52bd6c1332580bf00c2021-07-23T11:42:47ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-07-011210.3389/fimmu.2021.711060711060Metabolic Syndrome and Psoriasis: Mechanisms and Future DirectionsYan Hao0Ya-juan Zhu1Song Zou2Pei Zhou3Ya-wen Hu4Qi-xiang Zhao5Lin-na Gu6Hao-zhou Zhang7Zhen Wang8Zhen Wang9Zhen Wang10Jiong Li11State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, ChinaDepartment of Biotherapy and Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, ChinaState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, ChinaState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, ChinaState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, ChinaState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, ChinaState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, ChinaDepartment of Liver Surgery & Liver Transplantation, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, ChinaLaboratory of Liver Surgery, West China Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, ChinaPsoriasis is an immune-mediated systemic disease with associated comorbidities, including metabolic syndrome (MetS) which contributes substantially to premature mortality in patients with psoriasis. However, the pathological mechanisms underlying this comorbidity are unclear. Studies have shown that the pathological parameters of psoriasis mediate the development of MetS. We reviewed the potential mechanisms which mediate the association between psoriasis and MetS, including endoplasmic reticulum stress, pro-inflammatory cytokine releases, excess production of reactive oxygen species, alterations in adipocytokine levels and gut microbiota dysbiosis. Here, we highlight important research questions regarding this association and offer insights into MetS research and treatment.https://www.frontiersin.org/articles/10.3389/fimmu.2021.711060/fullpsoriasismetabolic syndromegut microbiotainsulin resistanceautoimmunityobesity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yan Hao Ya-juan Zhu Song Zou Pei Zhou Ya-wen Hu Qi-xiang Zhao Lin-na Gu Hao-zhou Zhang Zhen Wang Zhen Wang Zhen Wang Jiong Li
spellingShingle	Yan Hao Ya-juan Zhu Song Zou Pei Zhou Ya-wen Hu Qi-xiang Zhao Lin-na Gu Hao-zhou Zhang Zhen Wang Zhen Wang Zhen Wang Jiong Li Metabolic Syndrome and Psoriasis: Mechanisms and Future Directions Frontiers in Immunology psoriasis metabolic syndrome gut microbiota insulin resistance autoimmunity obesity
author_facet	Yan Hao Ya-juan Zhu Song Zou Pei Zhou Ya-wen Hu Qi-xiang Zhao Lin-na Gu Hao-zhou Zhang Zhen Wang Zhen Wang Zhen Wang Jiong Li
author_sort	Yan Hao
title	Metabolic Syndrome and Psoriasis: Mechanisms and Future Directions
title_short	Metabolic Syndrome and Psoriasis: Mechanisms and Future Directions
title_full	Metabolic Syndrome and Psoriasis: Mechanisms and Future Directions
title_fullStr	Metabolic Syndrome and Psoriasis: Mechanisms and Future Directions
title_full_unstemmed	Metabolic Syndrome and Psoriasis: Mechanisms and Future Directions
title_sort	metabolic syndrome and psoriasis: mechanisms and future directions
publisher	Frontiers Media S.A.
series	Frontiers in Immunology
issn	1664-3224
publishDate	2021-07-01
description	Psoriasis is an immune-mediated systemic disease with associated comorbidities, including metabolic syndrome (MetS) which contributes substantially to premature mortality in patients with psoriasis. However, the pathological mechanisms underlying this comorbidity are unclear. Studies have shown that the pathological parameters of psoriasis mediate the development of MetS. We reviewed the potential mechanisms which mediate the association between psoriasis and MetS, including endoplasmic reticulum stress, pro-inflammatory cytokine releases, excess production of reactive oxygen species, alterations in adipocytokine levels and gut microbiota dysbiosis. Here, we highlight important research questions regarding this association and offer insights into MetS research and treatment.
topic	psoriasis metabolic syndrome gut microbiota insulin resistance autoimmunity obesity
url	https://www.frontiersin.org/articles/10.3389/fimmu.2021.711060/full
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Metabolic Syndrome and Psoriasis: Mechanisms and Future Directions

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