Evaluation of lentinan effects on cytochrome P450 activity in rats by a cocktail method

Objective(s): In this study, a cocktail of probe drugs was used to assess whether lentinan could influence the activities of rat enzymes CYP3A4, CYP2D6, CYP1A2, CYP2C19, and CYP2C9 in vivo. Materials and Methods: Fourteen days after intraperitoneal injection of lentinan, rats were given an oral dose...

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Bibliographic Details
Main Authors: Yiping Lin, Yanli Wei, Xiaoxia Hu, Mei-Ling Wu, Jingchan Yao, Xiaoqian Ying, Xiaoyan Fu, Mingxing Ding, Liman Qiao
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2019-03-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
CYP
Online Access:http://ijbms.mums.ac.ir/article_12194_e36ea5b976a2f89ce7525a89090adc1e.pdf