Synthesis of some Mannich base derivatives and their antimicrobial activity study

Synthesis of some Mannich base derivatives and their antimicrobial activity study

A series of 2-(phenyl)-2-(morpholin-4-yl)-N-phenylacetamide I–VII were synthesized by Mannich base method. Synthesized compounds I–VII were confirmed by IR, 1H NMR, 13C NMR, mass and elemental analyses. Synthesized compounds I–VII were screened for antibacterial activity against various bacterial st...

Full description

Bibliographic Details
Main Authors: A. Idhayadhulla, R. Surendra Kumar, A. Jamal Abdul Nasser, J. Selvin, Aseer Manilal
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Arabian Journal of Chemistry
Subjects:
Mannich condensation
Antibacterial activity
Antifungal activity
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535210002893
id doaj-c3a4ab1f8aca4077a64952c285797054
record_format Article
spelling doaj-c3a4ab1f8aca4077a64952c2857970542020-11-24T21:28:14ZengElsevierArabian Journal of Chemistry1878-53522014-12-017699499910.1016/j.arabjc.2010.12.025Synthesis of some Mannich base derivatives and their antimicrobial activity studyA. Idhayadhulla0R. Surendra Kumar1A. Jamal Abdul Nasser2J. Selvin3Aseer Manilal4P.G. & Research Department of Chemistry, Jamal Mohamed College, Tiruchirappalli 620 020, Tamil Nadu, IndiaP.G. & Research Department of Chemistry, Jamal Mohamed College, Tiruchirappalli 620 020, Tamil Nadu, IndiaP.G. & Research Department of Chemistry, Jamal Mohamed College, Tiruchirappalli 620 020, Tamil Nadu, IndiaDepartment of Microbiology, Bharathidasan University, Tiruchirappalli 620 024, Tamil Nadu, IndiaDepartment of Microbiology, Bharathidasan University, Tiruchirappalli 620 024, Tamil Nadu, IndiaA series of 2-(phenyl)-2-(morpholin-4-yl)-N-phenylacetamide I–VII were synthesized by Mannich base method. Synthesized compounds I–VII were confirmed by IR, 1H NMR, 13C NMR, mass and elemental analyses. Synthesized compounds I–VII were screened for antibacterial activity against various bacterial strains and compared with standard Ciprofloxacin at concentration 100 μg/mL and for antifungal activity against various fungal strains and compared with Clotrimazole at concentration 100 μg/mL; particularly 3-(4-chlorophenyl)-3-(morp holin-4-yl)-N-phenylpropanamide lll that has high antibacterial activity against Streptococcus epidermidis was compared with standard Ciprofloxacin.http://www.sciencedirect.com/science/article/pii/S1878535210002893Mannich condensationAntibacterial activityAntifungal activity
collection DOAJ
language English
format Article
sources DOAJ
author A. Idhayadhulla
R. Surendra Kumar
A. Jamal Abdul Nasser
J. Selvin
Aseer Manilal
spellingShingle A. Idhayadhulla
R. Surendra Kumar
A. Jamal Abdul Nasser
J. Selvin
Aseer Manilal
Synthesis of some Mannich base derivatives and their antimicrobial activity study
Arabian Journal of Chemistry
Mannich condensation
Antibacterial activity
Antifungal activity
author_facet A. Idhayadhulla
R. Surendra Kumar
A. Jamal Abdul Nasser
J. Selvin
Aseer Manilal
author_sort A. Idhayadhulla
title Synthesis of some Mannich base derivatives and their antimicrobial activity study
title_short Synthesis of some Mannich base derivatives and their antimicrobial activity study
title_full Synthesis of some Mannich base derivatives and their antimicrobial activity study
title_fullStr Synthesis of some Mannich base derivatives and their antimicrobial activity study
title_full_unstemmed Synthesis of some Mannich base derivatives and their antimicrobial activity study
title_sort synthesis of some mannich base derivatives and their antimicrobial activity study
publisher Elsevier
series Arabian Journal of Chemistry
issn 1878-5352
publishDate 2014-12-01
description A series of 2-(phenyl)-2-(morpholin-4-yl)-N-phenylacetamide I–VII were synthesized by Mannich base method. Synthesized compounds I–VII were confirmed by IR, 1H NMR, 13C NMR, mass and elemental analyses. Synthesized compounds I–VII were screened for antibacterial activity against various bacterial strains and compared with standard Ciprofloxacin at concentration 100 μg/mL and for antifungal activity against various fungal strains and compared with Clotrimazole at concentration 100 μg/mL; particularly 3-(4-chlorophenyl)-3-(morp holin-4-yl)-N-phenylpropanamide lll that has high antibacterial activity against Streptococcus epidermidis was compared with standard Ciprofloxacin.
topic Mannich condensation
Antibacterial activity
Antifungal activity
url http://www.sciencedirect.com/science/article/pii/S1878535210002893
work_keys_str_mv AT aidhayadhulla synthesisofsomemannichbasederivativesandtheirantimicrobialactivitystudy
AT rsurendrakumar synthesisofsomemannichbasederivativesandtheirantimicrobialactivitystudy
AT ajamalabdulnasser synthesisofsomemannichbasederivativesandtheirantimicrobialactivitystudy
AT jselvin synthesisofsomemannichbasederivativesandtheirantimicrobialactivitystudy
AT aseermanilal synthesisofsomemannichbasederivativesandtheirantimicrobialactivitystudy
_version_ 1725971552841760768

Similar Items