AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy
AMPK integrates information about a cell’s energy status to inform decisions about cellular processes, including autophagy. Here the authors identify cyclin Y as an AMPK substrate, which phosphorylates cyclin Y and promotes its interaction with CDK16 to stimulate autophagy.
Bibliographic Details
| Main Authors: |
Marc Dohmen,
Sarah Krieg,
Georgios Agalaridis,
Xiaoqing Zhu,
Saifeldin N. Shehata,
Elisabeth Pfeiffenberger,
Jan Amelang,
Mareike Bütepage,
Elena Buerova,
Carolina M. Pfaff,
Dipanjan Chanda,
Stephan Geley,
Christian Preisinger,
Kei Sakamoto,
Bernhard Lüscher,
Dietbert Neumann,
Jörg Vervoorts |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-02-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-14812-0
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