Fitness Trade-Offs Associated with the Evolution of Resistance to Antifungal Drug Combinations

The evolution of drug resistance threatens human health worldwide. An emerging strategy to mitigate drug resistance is combination therapy. The fate of multidrug-resistant pathogens depends on their fitness relative to susceptible counterparts, yet the fitness consequences of multidrug resistance re...

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Bibliographic Details
Main Authors: Jessica A. Hill, Teresa R. O’Meara, Leah E. Cowen
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715000108