Hypolipidemic and antioxidative effects of Curcumin on blood parameters, humoral immunity, and jejunum histology in Hy-line hens

• Main Authors: Javad Arshami, Mohammad Pilevar, Mohammad Aami Azghadi, Ahmad Reza Raji
• Format: Article
• Language: English
• Published: Mashhad University of Medical Sciences 2013-04-01
• Series: Avicenna Journal of Phytomedicine
• Subjects: Curcumin; Humoral immunity; Hypolipidemic Agent; Jejunum Histology
• Online Access: http://ajp.mums.ac.ir/pdf_72_82455463c3d438bac4df306956af80d3.html

Objective: Turmeric (Curcuma Longa Linn) is a medicinal plant that contains curcumin. There is a growing interest in using curcumin powder (CP) as feed additives for antioxidative and antimicrobial properties to improve human health. This study was conducted to determine the appropriate levels of CP on blood parameters, immunity, and histology of jejunum in hens. Materials and Methods: A total of 200, 58-wk-old Hy-line hens were randomly distributed into 4 treatments (0%, 0.5%, 1.5%, and 2.5% CP or 0, 5, 15, and 25 g/kg feed, respectively) with 5 replicates (10 birds each) for 8 weeks using the completely randomized design. Blood samples were taken from 2 birds per replicate at weeks 61 and 65 to evaluate blood parameters. On weeks 63 and 65, two birds from each replicate received 0.5 ml SRBC (25%) injection in breast muscle and 7 days later, blood samples were collected to evaluate total Ig, IgG, and IgM titers in serum. Two hens were sacrificed at week 65 for the histological study of  jejunum. Results: Curcumin reduced triglycerides at 1.5% and 2.5% and cholesterol and LDL at 2.5% (p