Medication-related osteonecrosis of the jaws after tooth extraction in senescent female mice treated with zoledronic acid: Microtomographic, histological and immunohistochemical characterization.

Medication-related osteonecrosis of the jaws after tooth extraction in senescent female mice treated with zoledronic acid: Microtomographic, histological and immunohistochemical characterization.

Treatment with cumulative dosages of zoledronic acid (ZA) in elderly patients is a risk factor for the development of medication-related osteonecrosis of the jaws (MRONJ), mainly related to surgical triggers such as tooth extraction. However, animal models for the investigation and understanding of...

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Main Authors: Claudia Cristina Biguetti, André Hergesel De Oliva, Kent Healy, Ramez Hassan Mahmoud, Isabela Do Carmo Custódio, Dulce Helena Constantino, Edilson Ervolino, Marco Antonio Hungaro Duarte, Walid D Fakhouri, Mariza Akemi Matsumoto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0214173

Internet

https://doi.org/10.1371/journal.pone.0214173

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