Acute effect of particulate matter pollution on hospital admissions for stroke among patients with type 2 diabetes in Beijing, China, from 2014 to 2018

• Main Authors: Xiangtong Liu, Zhiwei Li, Moning Guo, Jie Zhang, Lixin Tao, Xiaolin Xu, Aklilu Deginet, Feng Lu, Yanxia Luo, Mengmeng Liu, Mengyang Liu, Yue Sun, Haibin Li, Xiuhua Guo
• Format: Article
• Language: English
• Published: Elsevier 2021-07-01
• Series: Ecotoxicology and Environmental Safety
• Subjects: Particulate matter; Stroke; Type 2 diabetes; Comorbidities
• Online Access: http://www.sciencedirect.com/science/article/pii/S0147651321003122

Background: The health effect of particulate matter pollution on stroke has been widely examined; however, the effect among patients with comorbid type 2 diabetes (T2D) in developing countries has remained largely unknown. Methods: A time-series study was conducted to investigate the short-term effect of fine particulate matter (PM2.5) and inhalable particulate matter (PM10) on hospital admissions for stroke among patients with T2D in Beijing, China, from 2014 to 2018. An over-dispersed Poisson generalized additive model was employed to adjust for important covariates, such as weather conditions and long-term and seasonal trends. Results: A total of 159,298 hospital admissions for stroke comorbid with T2D were reported. Approximately linear exposure-response curves were observed for PM2.5 and PM10 in relation to stroke admissions among T2D patients. A 10 μg/m3 increase in the four-day moving average of PM2.5 and PM10 was associated with 0.14% (95% confidence interval [CI]: 0.05–0.23%) and 0.14% (95% CI: 0.06–0.22%) incremental increases in stroke admissions among T2D patients, respectively. A 10 μg/m3 increase in PM2.5 in the two-day moving average corresponded to a 0.72% (95% CI: 0.02–1.42%) incremental increase in hemorrhagic stroke, and a 10 μg/m3 increase in PM10 in the four-day moving average corresponded to a 0.14% (95% CI: 0.06–0.22%) incremental increase in ischemic stroke. Conclusions: High particulate matter might be a risk factor for stroke among patients with T2D. PM2.5 and PM10 have a linear exposure-response relationship with stroke among T2D patients. The study provided evidence of the risk of stroke due to particulate matter pollution among patients with comorbid T2D.