Characterization of LEF1 High Expression and Novel Mutations in Adult Acute Lymphoblastic Leukemia.

Characterization of LEF1 High Expression and Novel Mutations in Adult Acute Lymphoblastic Leukemia.

Aberrant activation of the Wnt pathway plays a pathogenetic role in tumors and has been associated with adverse outcome in acute lymphoblastic leukemia (ALL). Lymphoid enhancer binding factor 1 (LEF1), a key mediator of Wnt signaling, has been linked to leukemic transformation, and LEF1 mutations ha...

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Bibliographic Details
Main Authors: Xing Guo, Run Zhang, Juan Liu, Min Li, Chunhua Song, Sinisa Dovat, Jianyong Li, Zheng Ge
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4420493?pdf=render

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