On Verification of Atopic Phenotype of Bronchial Asthma in Children

• Main Authors: O.V. Belashova, U.I. Marusik
• Format: Article
• Language: English
• Published: Publishing House Zaslavsky 2014-02-01
• Series: Zdorovʹe Rebenka
• Subjects: children; bronchial asthma; atopy; eosinophils; neutrophils
• Online Access: http://childshealth.zaslavsky.com.ua/article/view/75599
• ISSN: 2224-0551; 2307-1168

In order to establish the diagnostic value of the metabolic activity of blood granulocytes (eosinophils, neutrophils) in the verification of atopic phenotype of bronchial asthma (BA) in children there are formed two clinical groups. The first (I, basic) group formed 38 children with atopic BA (having a positive own and/or family allergic anamnesis history), II clinical group consisted of 26 patients with non-atopic BA. Groups were comparable by the main characteristics. As indicators of the functional state of neutrophil and eosinophil leukocytes, we determined their phagocytic activity (%), phagocytic number (c.u.), the intracellular content of eosinophil and neutrophil cationic protein (c.u.). It is found that in the development of atopic phenotype of BA in childhood there is a tendency to decrease in intracellular content of major cytotoxic agents (eosinophil cationic protein, peroxidase) in eosinophilic granulocytes of the blood. The decrease of phagocytic activity parameters (less than 60 %) and phagocytic number (less than 2.0 c.u.) of blood eosinophils is associated with a significantly higher risk of atopic bronchial asthma in children.