Molecular Control of Interdigital Cell Death and Cell Differentiation by Retinoic Acid during Digit Development

The precise coordination of cell death and cell differentiation during the formation of developing digits is essential for generating properly shaped limbs. Retinoic acid (RA) has a fundamental role in digit development; it promotes or inhibits the molecular expression of several critical genes. Thi...

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Main Authors: Martha Elena Díaz-Hernández, Alberto Jesús Rios-Flores, René Fernando Abarca-Buis, Marcia Bustamante, Jesús Chimal-Monroy
Format: Article
Language:English
Published: MDPI AG 2014-04-01
Series:Journal of Developmental Biology
Subjects:
FGF
Online Access:http://www.mdpi.com/2221-3759/2/2/138
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spelling doaj-c346eb624d604e1eb648006f8238f2572020-11-25T00:14:38ZengMDPI AGJournal of Developmental Biology2221-37592014-04-012213815710.3390/jdb2020138jdb2020138Molecular Control of Interdigital Cell Death and Cell Differentiation by Retinoic Acid during Digit DevelopmentMartha Elena Díaz-Hernández0Alberto Jesús Rios-Flores1René Fernando Abarca-Buis2Marcia Bustamante3Jesús Chimal-Monroy4Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, Apartado Postal 70228, México DF 04510, MexicoInstituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, Apartado Postal 70228, México DF 04510, MexicoInstituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, Apartado Postal 70228, México DF 04510, MexicoInstituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, Apartado Postal 70228, México DF 04510, MexicoInstituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, Apartado Postal 70228, México DF 04510, MexicoThe precise coordination of cell death and cell differentiation during the formation of developing digits is essential for generating properly shaped limbs. Retinoic acid (RA) has a fundamental role in digit development; it promotes or inhibits the molecular expression of several critical genes. This control of gene expression establishes molecular cascades that enable both the commencement of cell death and the inhibition of cell differentiation. In this review, we focus on the antagonistic functions between RA and fibroblast growth factor (FGF) signaling in the control of cell death and between RA and transforming growth factor beta (TGFβ) signaling in the control of cell differentiation.http://www.mdpi.com/2221-3759/2/2/138interdigital cell deathretinoic acidlimb developmentdigit formationapoptosisFGFTGFβ
collection DOAJ
language English
format Article
sources DOAJ
author Martha Elena Díaz-Hernández
Alberto Jesús Rios-Flores
René Fernando Abarca-Buis
Marcia Bustamante
Jesús Chimal-Monroy
spellingShingle Martha Elena Díaz-Hernández
Alberto Jesús Rios-Flores
René Fernando Abarca-Buis
Marcia Bustamante
Jesús Chimal-Monroy
Molecular Control of Interdigital Cell Death and Cell Differentiation by Retinoic Acid during Digit Development
Journal of Developmental Biology
interdigital cell death
retinoic acid
limb development
digit formation
apoptosis
FGF
TGFβ
author_facet Martha Elena Díaz-Hernández
Alberto Jesús Rios-Flores
René Fernando Abarca-Buis
Marcia Bustamante
Jesús Chimal-Monroy
author_sort Martha Elena Díaz-Hernández
title Molecular Control of Interdigital Cell Death and Cell Differentiation by Retinoic Acid during Digit Development
title_short Molecular Control of Interdigital Cell Death and Cell Differentiation by Retinoic Acid during Digit Development
title_full Molecular Control of Interdigital Cell Death and Cell Differentiation by Retinoic Acid during Digit Development
title_fullStr Molecular Control of Interdigital Cell Death and Cell Differentiation by Retinoic Acid during Digit Development
title_full_unstemmed Molecular Control of Interdigital Cell Death and Cell Differentiation by Retinoic Acid during Digit Development
title_sort molecular control of interdigital cell death and cell differentiation by retinoic acid during digit development
publisher MDPI AG
series Journal of Developmental Biology
issn 2221-3759
publishDate 2014-04-01
description The precise coordination of cell death and cell differentiation during the formation of developing digits is essential for generating properly shaped limbs. Retinoic acid (RA) has a fundamental role in digit development; it promotes or inhibits the molecular expression of several critical genes. This control of gene expression establishes molecular cascades that enable both the commencement of cell death and the inhibition of cell differentiation. In this review, we focus on the antagonistic functions between RA and fibroblast growth factor (FGF) signaling in the control of cell death and between RA and transforming growth factor beta (TGFβ) signaling in the control of cell differentiation.
topic interdigital cell death
retinoic acid
limb development
digit formation
apoptosis
FGF
TGFβ
url http://www.mdpi.com/2221-3759/2/2/138
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AT renefernandoabarcabuis molecularcontrolofinterdigitalcelldeathandcelldifferentiationbyretinoicacidduringdigitdevelopment
AT marciabustamante molecularcontrolofinterdigitalcelldeathandcelldifferentiationbyretinoicacidduringdigitdevelopment
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