Molecular Control of Interdigital Cell Death and Cell Differentiation by Retinoic Acid during Digit Development
The precise coordination of cell death and cell differentiation during the formation of developing digits is essential for generating properly shaped limbs. Retinoic acid (RA) has a fundamental role in digit development; it promotes or inhibits the molecular expression of several critical genes. Thi...
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doaj-c346eb624d604e1eb648006f8238f2572020-11-25T00:14:38ZengMDPI AGJournal of Developmental Biology2221-37592014-04-012213815710.3390/jdb2020138jdb2020138Molecular Control of Interdigital Cell Death and Cell Differentiation by Retinoic Acid during Digit DevelopmentMartha Elena Díaz-Hernández0Alberto Jesús Rios-Flores1René Fernando Abarca-Buis2Marcia Bustamante3Jesús Chimal-Monroy4Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, Apartado Postal 70228, México DF 04510, MexicoInstituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, Apartado Postal 70228, México DF 04510, MexicoInstituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, Apartado Postal 70228, México DF 04510, MexicoInstituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, Apartado Postal 70228, México DF 04510, MexicoInstituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, Apartado Postal 70228, México DF 04510, MexicoThe precise coordination of cell death and cell differentiation during the formation of developing digits is essential for generating properly shaped limbs. Retinoic acid (RA) has a fundamental role in digit development; it promotes or inhibits the molecular expression of several critical genes. This control of gene expression establishes molecular cascades that enable both the commencement of cell death and the inhibition of cell differentiation. In this review, we focus on the antagonistic functions between RA and fibroblast growth factor (FGF) signaling in the control of cell death and between RA and transforming growth factor beta (TGFβ) signaling in the control of cell differentiation.http://www.mdpi.com/2221-3759/2/2/138interdigital cell deathretinoic acidlimb developmentdigit formationapoptosisFGFTGFβ |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Martha Elena Díaz-Hernández Alberto Jesús Rios-Flores René Fernando Abarca-Buis Marcia Bustamante Jesús Chimal-Monroy |
spellingShingle |
Martha Elena Díaz-Hernández Alberto Jesús Rios-Flores René Fernando Abarca-Buis Marcia Bustamante Jesús Chimal-Monroy Molecular Control of Interdigital Cell Death and Cell Differentiation by Retinoic Acid during Digit Development Journal of Developmental Biology interdigital cell death retinoic acid limb development digit formation apoptosis FGF TGFβ |
author_facet |
Martha Elena Díaz-Hernández Alberto Jesús Rios-Flores René Fernando Abarca-Buis Marcia Bustamante Jesús Chimal-Monroy |
author_sort |
Martha Elena Díaz-Hernández |
title |
Molecular Control of Interdigital Cell Death and Cell Differentiation by Retinoic Acid during Digit Development |
title_short |
Molecular Control of Interdigital Cell Death and Cell Differentiation by Retinoic Acid during Digit Development |
title_full |
Molecular Control of Interdigital Cell Death and Cell Differentiation by Retinoic Acid during Digit Development |
title_fullStr |
Molecular Control of Interdigital Cell Death and Cell Differentiation by Retinoic Acid during Digit Development |
title_full_unstemmed |
Molecular Control of Interdigital Cell Death and Cell Differentiation by Retinoic Acid during Digit Development |
title_sort |
molecular control of interdigital cell death and cell differentiation by retinoic acid during digit development |
publisher |
MDPI AG |
series |
Journal of Developmental Biology |
issn |
2221-3759 |
publishDate |
2014-04-01 |
description |
The precise coordination of cell death and cell differentiation during the formation of developing digits is essential for generating properly shaped limbs. Retinoic acid (RA) has a fundamental role in digit development; it promotes or inhibits the molecular expression of several critical genes. This control of gene expression establishes molecular cascades that enable both the commencement of cell death and the inhibition of cell differentiation. In this review, we focus on the antagonistic functions between RA and fibroblast growth factor (FGF) signaling in the control of cell death and between RA and transforming growth factor beta (TGFβ) signaling in the control of cell differentiation. |
topic |
interdigital cell death retinoic acid limb development digit formation apoptosis FGF TGFβ |
url |
http://www.mdpi.com/2221-3759/2/2/138 |
work_keys_str_mv |
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