Transcript co-variance with Nestin in two mouse genetic reference populations identifies Lef1 as a novel candidate regulator of neural precursor cell proliferation in the adult hippocampus

Transcript co-variance with Nestin in two mouse genetic reference populations identifies Lef1 as a novel candidate regulator of neural precursor cell proliferation in the adult hippocampus

Adult neurogenesis, the lifelong production of new neurons in the adult brain, is under complex genetic control but many of the genes involved remain to be identified. In this study, we have integrated publicly available gene expression data from the BXD and CXB recombinant inbred mouse lines to dis...

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Bibliographic Details
Main Authors: David George Ashbrook, Anna eDelprato, Claudia eGrellmann, Mareike eKlein, Richard eWetzel, Rupert W Overall, Alexandra eBadea
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Neuroscience
Subjects:
bioinformatics
adult neurogenesis
BXD
neuroinformatics
Systems genetics
recombinant inbred mice
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00418/full

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