Novel fidaxomicin antibiotics through site-selective catalysis

Novel fidaxomicin antibiotics through site-selective catalysis

Fidaxomicin is a narrow spectrum antibiotic, and broadening its activity through structural modification could provide new antibiotics. Here semi-synthetic derivatives are prepared through site-selective esterification and allylic substitution to efficiently modify or substitute key carbohydrate moi...

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Main Authors: David Dailler, Andrea Dorst, Daniel Schäfle, Peter Sander, Karl Gademann
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-021-00501-6
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spelling doaj-c32e82beff5d448d939c9d14cc5a13142021-05-11T14:46:10ZengNature Publishing GroupCommunications Chemistry2399-36692021-05-014111110.1038/s42004-021-00501-6Novel fidaxomicin antibiotics through site-selective catalysisDavid Dailler0Andrea Dorst1Daniel Schäfle2Peter Sander3Karl Gademann4Department of Chemistry, University of ZurichDepartment of Chemistry, University of ZurichInstitute of Medical Microbiology, University of ZurichInstitute of Medical Microbiology, University of ZurichDepartment of Chemistry, University of ZurichFidaxomicin is a narrow spectrum antibiotic, and broadening its activity through structural modification could provide new antibiotics. Here semi-synthetic derivatives are prepared through site-selective esterification and allylic substitution to efficiently modify or substitute key carbohydrate moieties.https://doi.org/10.1038/s42004-021-00501-6
collection DOAJ
language English
format Article
sources DOAJ
author David Dailler
Andrea Dorst
Daniel Schäfle
Peter Sander
Karl Gademann
spellingShingle David Dailler
Andrea Dorst
Daniel Schäfle
Peter Sander
Karl Gademann
Novel fidaxomicin antibiotics through site-selective catalysis
Communications Chemistry
author_facet David Dailler
Andrea Dorst
Daniel Schäfle
Peter Sander
Karl Gademann
author_sort David Dailler
title Novel fidaxomicin antibiotics through site-selective catalysis
title_short Novel fidaxomicin antibiotics through site-selective catalysis
title_full Novel fidaxomicin antibiotics through site-selective catalysis
title_fullStr Novel fidaxomicin antibiotics through site-selective catalysis
title_full_unstemmed Novel fidaxomicin antibiotics through site-selective catalysis
title_sort novel fidaxomicin antibiotics through site-selective catalysis
publisher Nature Publishing Group
series Communications Chemistry
issn 2399-3669
publishDate 2021-05-01
description Fidaxomicin is a narrow spectrum antibiotic, and broadening its activity through structural modification could provide new antibiotics. Here semi-synthetic derivatives are prepared through site-selective esterification and allylic substitution to efficiently modify or substitute key carbohydrate moieties.
url https://doi.org/10.1038/s42004-021-00501-6
work_keys_str_mv AT daviddailler novelfidaxomicinantibioticsthroughsiteselectivecatalysis
AT andreadorst novelfidaxomicinantibioticsthroughsiteselectivecatalysis
AT danielschafle novelfidaxomicinantibioticsthroughsiteselectivecatalysis
AT petersander novelfidaxomicinantibioticsthroughsiteselectivecatalysis
AT karlgademann novelfidaxomicinantibioticsthroughsiteselectivecatalysis
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