Immunogenetics of Small Ruminant Lentiviral Infections

The small ruminant lentiviruses (SRLV) include the caprine arthritis encephalitis virus (CAEV) and the Maedi-Visna virus (MVV). Both of these viruses limit production and can be a major source of economic loss to producers. Little is known about how the immune system recognizes and responds to SRLVs...

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Bibliographic Details
Main Authors: Nancy Stonos, Sarah K. Wootton, Niel Karrow
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:Viruses
Subjects:
Online Access:http://www.mdpi.com/1999-4915/6/8/3311
Description
Summary:The small ruminant lentiviruses (SRLV) include the caprine arthritis encephalitis virus (CAEV) and the Maedi-Visna virus (MVV). Both of these viruses limit production and can be a major source of economic loss to producers. Little is known about how the immune system recognizes and responds to SRLVs, but due to similarities with the human immunodeficiency virus (HIV), HIV research can shed light on the possible immune mechanisms that control or lead to disease progression. This review will focus on the host immune response to HIV-1 and SRLV, and will discuss the possibility of breeding for enhanced SRLV disease resistance.
ISSN:1999-4915