Antagonism of miR-328 increases the antimicrobial function of macrophages and neutrophils and rapid clearance of non-typeable Haemophilus influenzae (NTHi) from infected lung.

Antagonism of miR-328 increases the antimicrobial function of macrophages and neutrophils and rapid clearance of non-typeable Haemophilus influenzae (NTHi) from infected lung.

Pathogenic bacterial infections of the lung are life threatening and underpin chronic lung diseases. Current treatments are often ineffective potentially due to increasing antibiotic resistance and impairment of innate immunity by disease processes and steroid therapy. Manipulation miRNA directly re...

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Bibliographic Details
Main Authors: Hock L Tay, Gerard E Kaiko, Maximilian Plank, JingJing Li, Steven Maltby, Ama-Tawiah Essilfie, Andrew Jarnicki, Ming Yang, Joerg Mattes, Philip M Hansbro, Paul S Foster
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-04-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4404141?pdf=render

Internet

http://europepmc.org/articles/PMC4404141?pdf=render

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