Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling

Metabolic remodeling plays an important role in pathological cardiac hypertrophy. Here, the authors show that hexosamine biosynthetic pathway is elevated in the heart by pressure overload, which contributes to heart failure by persistent activation of mTOR.

Bibliographic Details
Main Authors:	Diem Hong Tran, Herman I. May, Qinfeng Li, Xiang Luo, Jian Huang, Guangyu Zhang, Erica Niewold, Xiaoding Wang, Thomas G. Gillette, Yingfeng Deng, Zhao V. Wang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-15640-y

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spelling	doaj-c31f594008b74ae48fead9d2a15351c92021-05-11T09:16:24ZengNature Publishing GroupNature Communications2041-17232020-04-0111111510.1038/s41467-020-15640-yChronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodelingDiem Hong Tran0Herman I. May1Qinfeng Li2Xiang Luo3Jian Huang4Guangyu Zhang5Erica Niewold6Xiaoding Wang7Thomas G. Gillette8Yingfeng Deng9Zhao V. Wang10Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical CenterDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical CenterDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical CenterDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical CenterDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical CenterDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical CenterDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical CenterDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical CenterDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical CenterTouchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical CenterDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical CenterMetabolic remodeling plays an important role in pathological cardiac hypertrophy. Here, the authors show that hexosamine biosynthetic pathway is elevated in the heart by pressure overload, which contributes to heart failure by persistent activation of mTOR.https://doi.org/10.1038/s41467-020-15640-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Diem Hong Tran Herman I. May Qinfeng Li Xiang Luo Jian Huang Guangyu Zhang Erica Niewold Xiaoding Wang Thomas G. Gillette Yingfeng Deng Zhao V. Wang
spellingShingle	Diem Hong Tran Herman I. May Qinfeng Li Xiang Luo Jian Huang Guangyu Zhang Erica Niewold Xiaoding Wang Thomas G. Gillette Yingfeng Deng Zhao V. Wang Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling Nature Communications
author_facet	Diem Hong Tran Herman I. May Qinfeng Li Xiang Luo Jian Huang Guangyu Zhang Erica Niewold Xiaoding Wang Thomas G. Gillette Yingfeng Deng Zhao V. Wang
author_sort	Diem Hong Tran
title	Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling
title_short	Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling
title_full	Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling
title_fullStr	Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling
title_full_unstemmed	Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling
title_sort	chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-04-01
description	Metabolic remodeling plays an important role in pathological cardiac hypertrophy. Here, the authors show that hexosamine biosynthetic pathway is elevated in the heart by pressure overload, which contributes to heart failure by persistent activation of mTOR.
url	https://doi.org/10.1038/s41467-020-15640-y
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Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling

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