Renin-Secreting Ovarian Adult Granulosa Cell Tumor in a Patient With New-Onset Hypertension and Hypokalemia

• Main Authors: Rowan Karaman, MD, Jin Xu, MD, Ross F. Harrison, MD, David M. Kushner, MD, Paul S. Weisman, MD, Yoram Shenker, MD
• Format: Article
• Language: English
• Published: Elsevier 2019-03-01
• Series: AACE Clinical Case Reports
• Online Access: http://www.sciencedirect.com/science/article/pii/S2376060520305204
• ISSN: 2376-0605

ABSTRACT: Objective: To describe a case of a renin-secreting ovarian tumor, which is a rare cause of hyperreninemia leading to secondary hypertension and hypokalemia.Methods: We present the first case of a patient with a molecularly confirmed renin-secreting ovarian adult granulosa cell tumor.Results: A 31-year-old female presented with hypertension and amenorrhea. She was found to have spontaneous hypokalemia. Computed tomography scan showed a pelvic mass which was resected and found to be a renin-secreting ovarian adult granulosa cell tumor. The hypertension and hypokalemia resolved after the mass was resected.Conclusion: Renin-secreting ovarian adult granulosa cell tumors are rare causes of hyperreninemia leading to hypertension and hypokalemia.Abbreviations: GCT = granulosa cell tumor; RAAS = renin-angiotensin-aldosterone system